Publikationen
AGO 36 SHAPE
(Prim. Dr. Carmen Siebenhofer)
Eine randomisierte Phase III-Studie mit radikaler Hysterektomie und pelviner Lymphknotendissektion im Vergleich mit einfacher Hysterektomie und pelviner Lymphknotendissektion bei Patientinnen mit risikoarmem Zervixkarzinom im Frühstadium.
AGO 52 Atalante
(OÄ Dr. Ursula Sevelda)
Eine randomisierte doppelblinde Phase-III-Studie mit Atezolizumab versus Placebo bei Patientinnen mit spätrezidivierendem epithelialem Ovarial-, Tuben- oder Peritonealkarzinom zur Behandlung mit platinbasierter Chemotherapie und Bevacizumab.
DAMASCUS
(Prim. Prof. Dr. Felix Aigner, MBA FEBS FACS)
Internationale, prospektive Snapshot-Kollaborationsstudie über die akute Divertikulitis.
https://www.acpgbi.org.uk/about/news/355/damascus_study/
https://doi.org/10.1016/j.eclinm.2025.103548
EAGLE
(F. Aigner, G. Moitzi, G. Gemes, M. Braumille, M. Mitteregger, S. Gerald, S. Uranitsch)
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Efficacy assessment following shortened venetoclax exposure in AML patients treated with venetoclax plus hypomethylating agents: a real-world, multicentric study
(Wurm S, Moritz JM, Petzer V, Wolf D, Gleixner KV, Sperr WR, Groiss C, Machherndl-Spandl S, Eisenwort G, Koller E, Schoeche J, Petrasch C, Singer J, Mayer DM, Pregartner G, Heine A, Wölfler A, Sill H, Reinisch A, Zebisch A.)
CLASSICA
(PI Prim. Prof. Dr. F. Aigner)
Validierung mathematischer Methoden und künstlicher Intelligenz für die Klassifizierung von Krebs in der Echtzeitchirurgie.
Die Studie ist ein, von der EU Horizon Europe gefördertes Projekt an dem 11 internationale Zentren, davon 5 klinische Partner, teil.
Ziel ist es, aufgrund von Perfussionsmustern von Rektumtumoren eine KI zu programmieren, die bereits intraoperativ benignes von malignem Gewebe unterscheiden kann.
CLASSICA – Validating AI in classifying cancer in real-time surgery
Colitis associated with persistent drug-induced immune dysregulation
(Köhler J, Hammerl R, Mayer DM, Fessler J, Langner C.)
Adverse drug reactions frequently involve the gastrointestinal tract. We present two cases of colitis that occurred months to years after chemotherapy and autologous stem cell transplantation for the treatment of lymphoma. Laboratory tests revealed altered immune status with decreased CD4/CD8 ratio and hypogammaglobinemia (in one patient). The patients had no history of inflammatory bowel disease or immunodeficiency. Biopsies showed chronic active colitis with crypt architectural distortion, erosions, and ulcers as well as pyloric gland metaplasia and loss of plasma cells (in one patient, respectively). Colitis appeared to be related to lymphoma therapy, but could not be attributed to a distinct drug or infectious agent, suggesting the concept of persistent immune dysregulation driving mucosal inflammation. Hence, we suggest "immune dysregulation-associated colitis" (ID-colitis) as an umbrella term for cases of chronic colitis, in which immune dysfunction is evident from blood samples or clinical information and inflammatory bowel disease has been ruled out.
Colitis associated with persistent drug-induced immune dysregulation - PubMed
HIPPO
(Prim. Prof. Dr. Felix Aigner, MBA FEBS FACS)
Eine globale Kohortenstudie um den Rückstau von elektiven Leistenbrüchen durch die Pandemie zu erheben-und Strategien zur Optimierung für diesen elektiven chirurgischen Weg zu finden.
https://www.globalsurgeryunit.org/clinical-trials-holding-page/hippo/
NIHR Global Health Research Unit on Global Surgery
(Prim. Prof. Dr. Felix Aigner, MBA FEBS FACS)
Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries
https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00142-6/fulltext
Stoma-free survival after anastomotic leak following rectal cancer resection
(Prim. Prof. Dr. Felix Aigner, MBA FEBS FACS, OA DR. Martin Mitteregger, MBA, FEBS)
THYHEART
(FÄ Dr. Beatrice Egger)
Validating artificial intelligence in classifying cancer in real time during surgery
(Prim. Prof. Dr. Felix Aigner, MBA FEBS FACS)
https://onlinelibrary.wiley.com/doi/full/10.1111/codi.16769